Credelio for Dogs

Medical review by K9 Healthcare Council of America (K9HCA). Intended for educational purposes only. Always seek medical advice from your veterinarian.

Credelio for Dogs

As pet owners, our furry companions hold a special place in our hearts—a place filled with boundless love, unwavering loyalty, and cherished memories.

Our pets are not just animals; they are family members who bring joy, comfort, and companionship to our lives. With every wag of their tail or gentle purr, they remind us of the simple yet profound bond we share.

Yet, amidst the laughter and cuddles, there exists a silent threat that lurks in the shadows, waiting to disrupt the harmony of our shared moments: fleas. These tiny pests, barely visible to the naked eye, have the power to turn our homes into battlegrounds, our pets into uneasy hosts, and our hearts heavy with worry.

Credelio for dogs fleas
Credelio for dogs fleas. For every pet owner who has witnessed the discomfort of their beloved companion scratching incessantly or seen the telltale signs of flea infestation, the struggle is all too real. It’s a battle against an adversary that seems relentless, leaving us feeling helpless and desperate for a solution.

In this article we’ll review the oral flea medication Credelio for dogs and reveal the risks & side effects as well as provide alternative all-natural means for more promising relief and effective protection from fleas.

What Is Credelio for Dogs?

Credelio is an oral medication available by prescription only used for dogs to prevent and control fleas and ticks. It’s given as a monthly dose.

Credelio’s active ingredient is Lotilaner, which is a member of the isoxazoline class of parasiticides. Isoxazoline’s have been associated with neurologic adverse reactions including tremors, ataxia, and seizures.

What Are Isoxazolines?

Isoxazolines are a class of chemical compounds used as parasiticides to control fleas and ticks in pets. They work by disrupting the normal functioning of the insects’ central nervous system, causing them to become paralyzed and die.

Fluralaner, afoxolaner, and lotilaner are examples of isoxazoline and are found in numerous flea and tick parasiticides products including Bravecto, Nexgard, Simparica and Revolution Plus, which are also isoxazolines.

Credelio for dogs dosage by weight. Credelio for dogs 50 - 100 lbs. Credelio for Dogs 6 12 lbs. Credelio for Dogs 12 25 lbs.
Credelio for dogs is a neuroloxin that kills fleas and ticks by paralyzing them. This means it can also cause neurological adverse reactions in dogs.

Is Credelio Safe for Dogs?

No, it isn’t. Like all isoxazolines, Credelio is a neuroloxin that kills fleas and ticks by paralyzing them. This means it can also cause neurological adverse reactions in dogs.

In spite of that, manufacturers report that isoxazolines don’t have the same effect on dogs and cats as on insects (based on the differences in sensitivity of insects and acarines’ GABA receptors versus mammalian GABA receptors).

However, there are social media pages devoted to telling the stories of dogs who have had minor and major side effects, including seizures, after taking isoxazolines.

Credelio for Dogs Side Effects

During the manufacturers field studies of Credelio, various multiple side effects in dogs were reported. These adverse reactions included: diarrhea, vomiting, elevated BUN (blood urea nitrogen), polyuria (excessive urination) and elevated potassium.

Other dogs experienced elevated creatinine and weight loss. One dog with a history of seizures experienced seizure activity (tremors and glazed eyes) six days after receiving oral doses of Credelio.

According to an fact sheet, isoxazoline products have been associated with neurologic adverse reactions including:

  • Muscle tremors & spasms
  • Ataxia (loss of coordination)
  • Seizures (even in dogs without a history of seizures)

Does Credelio Treat Dermatitis in Dogs?

No, it doesn’t treat skin dermatitis. The manufacturers of Credelio say it can be used as part of the management of flea allergy dermatitis. But Credelio does not treat skin dermatitis directly. While it can aid in managing flea allergy dermatitis by killing or paralyzing fleas, it doesn’t alleviate or treat the itch associated with skin dermatitis.

What is the Recommended Dosage of Credelio for Dogs?

Credelio for Dogs Dosage Schedule:

Credelio for Dogs 04  06 lbs – One 56.25 mg chewable tablet

Credelio for Dogs 6 12 lbs – One 112.5 mg chewable tablet

Credelio for Dogs 12 25 lbs – One 225 mg chewable tablet

Credelio for Dogs 25 50 lbs – One 450 mg chewable tablet

Credelio for Dogs 50 100 lbs – One 900 mg chewable tablet

Credelio for Dogs over 100 lbs – Administer the appropriate combination of chewable tablets.

Credelio for dogs dosage by weight chart
CREDELIO for dogs is available in five chewable tablet sizes for use in dogs: 56.25, 112.5, 225, 450, and 900 mg lotilaner. Each chewable tablet size is available in color-coded packages of 1, 3 or 6 chewable tablets.

Natural Alternatives to Credelio for Dogs

Herbal Remedies

There are many herbal remedies that can repel fleas and ticks. If you buy a pre-made product, look for ingredients like neem oil, lavender, sage or lemon juice. Herbal Flea Collars infused with natural flea-repelling herbs like neem, eucalyptus, or cedar can provide ongoing protection against fleas.

Essential Oils

Some essential oils, such as lavender, peppermint, and citronella, have natural flea-repellent properties. Diluted forms can be applied to a dog’s coat or used in homemade flea sprays. Essential oils should never be used undiluted. Always dilute them in a carrier oil like almond oil at the ratio of 2-3 drops of essential oil per ounce of carrier oil.

Apple Cider Vinegar

Adding diluted apple cider vinegar to a dog’s drinking water can help repel fleas due to its acidity. Use apple cider vinegar to create a higher pH in your dog to discourage parasites. You can dilute it 1:1 with water and spray or rub it through your dog’s coat. Use a cotton ball to dab it behind your dog’s ears, armpits and groin, but avoid use on raw areas, as it will sting.

Or feed it to your dog by adding 1 – 2 Tbs to a quart of water in his water bowl. If he doesn’t like the taste, use less. You can also stir some into your dog’s food. Use ¼ teaspoon for small animals and up to a tablespoon for large dogs. It can also be used as a rinse after bathing.

Diatomaceous Earth

Diatomaceous earth is made from crushed fossils of marine life with razor-sharp shards that pierce the shell and larvae so the insect dehydrates and dies. Sprinkle onto your pet’s coat and rub it in, then brush the coat to remove the dried mixture. Food-grade diatomaceous earth can be sprinkled on carpets, bedding, and outdoor areas to kill fleas by dehydrating them.

Flea-Repelling Shampoos

Natural shampoos containing ingredients like neem oil, tea tree oil, or oatmeal can help deter and soothe flea infestations.

Flea-Repelling Supplements

Some supplements, such as brewer’s yeast or garlic, when added to a dog’s diet, can help repel fleas through their odor.

Regular Grooming

Brushing your dog’s coat regularly helps remove fleas and flea eggs, reducing infestation risk.


Regular vacuuming of carpets, upholstery, and pet bedding helps remove fleas and their eggs from the environment.

CBD Products

A healthy skin and coat are essential for repelling and resisting fleas and ticks. CBD oil contains fatty acids and nutrients that can help support skin health and coat condition, potentially making it less hospitable for pests.

CBD (cannabidiol) products, such as oils or treats, are gaining popularity for their potential to support overall wellness in dogs, including stress reduction and potentially reducing inflammation associated with flea bites.

Credelio for dogs natural alternatives
Improving Overall Wellness: CBD oil is thought to have various health benefits for dogs, including supporting joint health, promoting relaxation, and enhancing overall well-being. A dog that is in good health may be better equipped to fend off pests like fleas and ticks.

These natural alternatives can be effective for flea prevention and management, but it’s essential to consult with a veterinarian before starting any new treatment regimen for your dog’s health and safety.

FAQ’s About Credelio for Dogs

Q: How does Credelio work to treat fleas in dogs?

A: Credelio contains the active ingredient lotilaner, which is a flea and tick preventative that works by disrupting the nervous system of fleas and ticks upon contact with your dog’s blood. This disrupts their ability to feed, ultimately leading to their demise.

Q: Is Credelio safe for all dogs?

A: Credelio is considered by some vets as “generally safe” for dogs, but can have serious side effects, so it’s essential to follow dosage instructions provided by your veterinarian. It’s important to note that Credelio is only approved for use in dogs weighing over 4.4 pounds and at least 8 weeks of age. Be sure to consult your vet before administering Credelio, especially if your dog has a history of sensitivities or health issues.

Q: What are the potential side effects of Credelio?

While Credelio is considered safe for most dogs, some potential side effects may include vomiting, diarrhea, lethargy, and decreased appetite. More serious adverse reactions such as seizures have been noted in dogs given Credelio. If you notice any unusual symptoms after giving Credelio to your dog, contact your veterinarian immediately.

Q: Are there natural alternatives to Credelio for flea treatment?

Yes, there are natural alternatives to Credelio for flea treatment. Options include essential oils, herbal flea collars, diatomaceous earth, and CBD products. CBD oil, for instance, is gaining popularity for its potential to support overall wellness in dogs, including potentially reducing inflammation associated with flea bites.

Q: How often should I administer Credelio to my dog?

A: Credelio is typically administered orally once a month. It’s important to maintain a regular schedule to ensure continuous protection against fleas and ticks. If you miss a dose, administer it as soon as you remember, and resume your regular monthly schedule. If you’re unsure about the dosage or frequency, consult your veterinarian for guidance.

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