Dog Separation Anxiety
Author’s Update: This article was originally published on December 15, 2017. Preliminary data presented since at the 2019 Annual International Cannabinoid Research (ICRS) featured new developments in CBD science that have far-reaching implications for many areas of medicine.
Harvard University scientist Staci Gruber shared encouraging results from the first open-label to double-blind clinical trial assessing the impact of a high-CBD, low-THC sublingual tincture in patients who experience moderate anxiety. CBD performed well at relieving panic attacks, mitigating mood swings, and quelling feelings of agitation, irritability, and sadness.
Specifically, findings suggest that the use of a custom-formulated, whole plant-derived high CBD sublingual tincture results in less severe anxiety and was associated with less anxiety-related symptoms. Click To TweetAt the Veterinary Information Network (VIN) in 2019 a survey to gauge US veterinarians’ knowledge level, views and experiences related to the use of cannabinoids in the medical treatment of dogs found that most vets agreed that hemp derived CBD products offer benefits for humans and expressed support for use of CBD products for companion animals.
How To Help a Dog with Separation Anxiety?
There are many prescriptions and over-the-counter medications available for anxiety-related disorders, but many pet parents are tired of synthetic chemical medications and are wanting a more natural, organic remedy to help soothe and calm their four-legged friends.

Separation Anxiety in Dogs – Natural Therapy to Help Anxious Dogs
Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically wide-spectrum phytonutrient that in recent years has drawn increasing interest as a treatment for a wide range of human neuro-psychiatric disorders.
Not surprising, CBD for dogs has also been getting a lot of attention lately because it may provide some of the same interesting therapeutic effects for pets suffering from behavioral issues like social interaction disorders, depression and separation anxiety.
CBD For Dogs Anxiety

Treatment For Anxious Dogs – CBD For Canine Separation Anxiety
CBD is a natural treatment alternative for dogs with Canine Anxiety Disorder but without dangerous, addictive side-effects and is perhaps the most promising dietary supplement for overall canine health to come out in the last 50 years.
Numerous studies and an accumulating body of potential evidence from clinical experiments show that CBD has strong anxiolytic (anti-anxiety) properties and is well-tolerated by dogs with symptoms of severe anxiety disorders.
Even though Cannabidiol has not been medically proven to be a cure or treatment for anxiety associated disorders, dog owners are still wantonly giving their pets CBD based products in hopes that it will relieve their dog’s high-anxiety panic symptoms & stress reactions, often with dramatic improvements using only small, incremental doses.
Does Hemp Oil Help Dogs with Separation Anxiety?
Several studies have been conducted that establish the efficacy of CBD-rich hemp oil in improving the destructive behaviors of canine separation anxiety disorder.
Separation anxiety in dogs is a condition in which a dog exhibits distress and recurrent behavior problems in the absence or perceived absence of an attachment figure. An attachment figure could be its guardian, another human, or another animal.
Separation anxiety is the second most common behavior problem of canines affecting an estimated 14% to 40% of dogs. In addition to separation anxiety, these pets may have other panic disorders or phobias including nighttime panic, and phobias to thunderstorms or loud noises like exploding fireworks.

Symptoms Of Dogs with Anxiety
The signs associated with separation anxiety typically begin right before or just after the attachment figure leaves. Dogs suffering from separation anxiety typically exhibit behaviors like pacing, excessive salivating, barking, howling, whining or destructive chewing.
In more extreme cases, dogs will vomit, urinate, defecate or scratch and dig at doors or windows in escape attempts to try to reunite with their owner.
It is not fully understood why some dogs present symptoms of separation anxiety while other dogs do not.
Dogs With Separation Anxiety Breeds
Mixed breeds may be more prone to separation anxiety than purebred dogs and male dogs may be at higher risk than females.
Though the exact cause of canine separation anxiety is not known, negative behaviors can be triggered or amplified in dogs by: a change in care or routine, by a traumatic life event like the loss of a pack family member (or a recent addition) or from a major life change like moving to a new home or abandonment to a shelter.
Separation anxiety behavior may also be due to a secondary underlying medical condition or accrue from repeated external stress that can cause lasting impairments to a dog’s physiological health. Over time, increased stress in a dog alters their endocrine hormone levels and thus decreases their immunity to various inflammatory based health problems.
What is clear is that anxious canine behaviors are not the result of disobedience or spite. Your dog displays anxious behaviors when left alone because he’s upset and trying to cope with and adapt to a great deal of stress!
This is where full spectrum hemp CBD oil can be very helpful for anxious dogs.

CBD For Calming Anxious Dogs
CBD for dogs can be a great therapeutic aid for separation anxiety and a natural alternative to the currently available pharmaceuticals especially when starting at low doses and working one’s way up to using higher amounts.
How CBD Works For Dogs with Separation Anxiety
CBD oil helps dogs with anxiety in two noticeable ways. First, at the cellular level, the Endocannabinoid System (ECS), comprised of the cannabinoid receptors CB1 and CB2, are widely distributed throughout the dog brain and modulates functions such as eating, sleeping, pain reception and mood. The activity of the ECS can be modified with exogenous CBD thus mediating the dog’s initial, acute ‘panic-reflex’ so he doesn’t progress into more negative behaviors.
CBD works by exerting several actions on a dog’s brain. CBD acts similar to a class of prescription anti-depressants, known as Selective Serotonin Reuptake Inhibitors (SSRI), by boosting nerve impulse signaling via serotonin receptors. In fact, some studies have shown that CBD can enhance the transmission effect on serotonin receptors faster than those of SSRI’s.
Second, and more broadly, CBD can help with ‘oxidative stress’ levels that may play a role in pre-determining those dogs that may be at risk for anxiety disorders. CBD’s primary action is as an anti-inflammatory, neuro-protectant (US Patent #6630507- Cannabinoids as neuroprotectants).
A study conducted in 2016 used primary metabolite profiling to identify possible biomarkers for anxiety-related behavior. Results identified changes in thirteen metabolites between dogs who had separation anxiety and those who did not; these changes included differences in metabolites which control lipid metabolism and oxidative stress responses.
Researchers were able to come to the conclusion that biomarkers such as primary metabolites play a prominent role in canine anxiety. CBD can help balance these basic metabolite by-products coming from repeated stress encounters, thereby controlling the over-all inflammatory effect on canine homeostasis, essentially calming the storm before it starts.

CBD Oil for Dogs with Separation Anxiety
Things To Consider Before Giving Your Dog CBD
Separation anxiety is a serious affliction that has potential to affect any dog and commonly results in destructive or otherwise inappropriate behavior. The goal of treatment is to help the animal feel comfortable when left alone and feel less panic related in the absence of the “attachment figure”.
The precise mechanisms involved in its anxiolytic action remain to be determined but since Cannabidiol is from an organic, plant-based phytonutrient with zero harmful side effects we can assume that supplementing your dog’s diet with CBD is safer than synthetic, prescription medications for anxiety-related canine disorders.
As mentioned earlier, clinical trials of this medication are still in their preliminary phases. However, considering the potential role that CBD can play as a natural therapeutic aid for canine anxiety-related disorders, CBD may eventually become the safer, more favorable first choice for treating your dog’s separation anxiety.

In addition to specifically addressing the separation anxiety by supplementing with CBD, the general well-being of your pet must be optimized by ensuring adequate exercise and intellectual stimulation (e.g., food puzzle toys).
Some pets may be more comfortable if a pet sitter is an option or in doggie daycare for working pet parents. Ancillary treatments such as pressure wraps can also be used in conjunction with CBD for a safe means to modify restless, destructive behaviors.
Remember, all dogs need attention, affection and stimulation to thrive; but if you’re curious about the efficacy of this medication as a treatment alternative, your best option is to simply try CBD for your dog!
Curtis has been passionate about the health and welfare of animals since his first dog rescue.
After studying Sports Medicine & Biology at the University of Oregon, Curtis went on to excel in a career of Clinical Nutrition, later owning a health care supplement company serving private-practice physicians.
Known for his expansive knowledge of natural health and alternative medicine, Curtis believes that natural plant-based therapies can be applied to veterinary animal care which led him to study the science of Cannabinoid Medicine. His expertise in Functional Medicine led him to formulate a unique hemp-based canine care product, Canine Support Formula, fulfilling a dream to combine natural pet-care strategies with the new therapeutic potential of medical cannabis.
In reverence for his own dog, Parker, Curtis has dedicated his company–K9 Medibles–to improving the health and longevity of all dogs.
To learn more about Curtis and how K9 Medibles can help your dog, click HERE.
Yep, Kandi Lea before CBD would get in the garbage & shred every tissue she could get when left home alone. Used to drool all over in car when riding too. After CBD no more anxiety only during fireworks or thunderstorms of which I just give extra doses of Canine Support Formula. Thank you Curtis for this awesome formula you created for our pets.